COMPUTATIONAL LIFE EXPERIENCE

WHAT WE DO?

We design and optimize medical devices using the Digital Avatar, a digital version of the human body.

With it, it is possible to:

The Digital Avatar Platform reduces time and costs associated with the research and development of medical devices in pre-clinical and clinical phases.

It is a highly innovative testing platform that integrates several components of the human body in a tightly integrated manner and represents
the solution for MedTech companies that need to understand the effect of medical devices on the whole body. It solves the uncertainties connected
to animal testing and multiple parameter measurements at several locations.

MATHEMATICS AND MEDICINE COME TOGETHER

SOFTWARE VALIDATION

Computational Life’s software replicates all body fluid mechanisms into a single, integrated platform based on the state-of-the-art of mathematical modeling. Our software is currently able to simultaneously simulate the dynamics of the:

• Arterial and venous system;
• Heart;
• Microcirculation;
• Pulmonary circulation;
• Cerebrospinal fluid;

The mathematical modeling relies on basic validated physical laws of fluid dynamics. The hemodynamics of the Digital Avatar have been validated using peer-reviewed articles in the healthy human body, and the computational waveforms closely resemble in-vivo measurements in healthy subjects.
 

The Digital Avatar is highly flexible and allows the simulation of both healthy and unhealthy scenarios with and without medical devices that influence the body.

Currently, the entire cardiovascular system is already integrated on the platform. We are working on adding the Respiratory and Renal Systems and will expand to other systems in the future.

We can currently simulate:

      - Left ventricular assist devices;
      - Right ventricular assist devices;
      - Bi-ventricular assist devices;

We are currently working on medical device models to integrate into our Digital Avatar, such as:

      - Cardiac assist devices:
                - External counterpulsation;
                - Intra-aortic balloon pump;
                - Percutaneous ventricular assist device;
                - C-Pulse heart assist system;
      - Electro-muscle stimulation to enhance blood flow;
      - Infusion pump;

There are several pathologies that can be simulated with our Digital Avatar. Here is a short list of the cases that we can study:

      - Stenotic or regurgitant cardiac valves (tricuspid, pulmonary, mitral
        and aortic valves);
      - Arterial or venous hypertension;
      - Arterial or venous stenosis (thoracic, common carotid, transverse
        sinus, etc.);
      - Arteriovenous fistula;
      - Deep venous thrombosis;

MATHEMATICS AND MEDICINE COME TOGETHER

ROADMAP